Bovine Microcrystalline Hydroxyapatite (MCHA) Canada Tooth Remineralizing

Introduction

Bovine-derived Microcrystalline Hydroxyapatite (MCHA) is a natural form of calcium phosphate sourced from bovine bone, closely mimicking the mineral structure of human tooth enamel and dentin. In oral care products like toothpastes, MCHA acts as a bioactive agent to promote enamel remineralization, reduce sensitivity, and protect against demineralization from acids, plaque, and daily wear. Bovine MCHA retains trace elements and structural similarities that enhance its biomimetic integration with tooth surfaces.

This document provides evidence-based insights from peer-reviewed studies (primarily via NIH/PubMed and PMC) on hydroxyapatite (HA/MCHA) in dental applications, with emphasis on forms tested on bovine models or microcrystalline variants. It supports the use of bovine MCHA in natural toothpastes for transparency and customer confidence.

Benefits of Bovine MCHA in Toothpaste

• Enamel Remineralization: Deposits hydroxyapatite crystals to repair demineralized areas, often comparable or superior to fluoride.

• Sensitivity Reduction: Occludes dentin tubules for relief from hot/cold/acidic stimuli.

• Erosion Protection: Forms a protective layer against acid attacks.

• Biocompatibility: Natural sourcing aligns with fluoride-free preferences.

• Overnight Efficacy: Leaving on enhances absorption, as per gentle brushing instructions.

Key Supporting Studies

Studies often use bovine enamel/dentin models due to similarity to human teeth. Microcrystalline HA (including bovine-derived) shows strong results.

1. Enamel and Dentine Remineralization by Nano-Hydroxyapatite Toothpastes (2011)¹ In vitro study on bovine enamel/dentin lesions. Nano-HA toothpastes showed higher remineralization than amine fluoride, especially in dentin.

2. The Use of Hydroxyapatite Toothpaste to Prevent Dental Caries (2022 Review)² Narrative review of in vitro/in situ/clinical studies. HA toothpastes (micro/nano) deposit on enamel, equivalent to fluoride in remineralization; bovine models confirmed superior effects in some formulations.

3. Impact of a Toothpaste with Microcrystalline Hydroxyapatite on Early Childhood Caries (2021 RCT)³ 1-year trial in children: Microcrystalline HA toothpaste non-inferior to fluoride in preventing caries progression.

4. Remineralization of Molar Incisor Hypomineralization (MIH) with Hydroxyapatite Toothpaste (2022 In-Situ Study)⁴ Crossover study: 20% microcrystalline HA achieved ~26% remineralization vs. ~15% for fluoride.

5. Caries-Preventing Effect of Hydroxyapatite Toothpaste in Adults (2023 RCT)⁵ 18-month trial: HA toothpaste equivalent to fluoride in preventing caries, safe for all ages.

Additional evidence from reviews supports HA's role in sensitivity relief and biofilm control.⁶⁻⁸

Safety and Transparency

Bovine MCHA is biocompatible and GRAS for oral use when properly sourced/processed. No adverse effects in studies. Our toothpaste uses ethically sourced bovine MCHA at optimal concentrations, fluoride-free and additive-free.

Document updated January 2026 based on public research. Consult a dentist for advice.

Footnotes ¹ Tschoppe P, et al. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J Dent. 2011;39(6):430-437. https://pubmed.ncbi.nlm.nih.gov/21504777/

² Amaechi BT, et al. The use of hydroxyapatite toothpaste to prevent dental caries. Odontology. 2022;110(2):979-993. https://pmc.ncbi.nlm.nih.gov/articles/PMC8930857/

³ Paszynska E, et al. Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial. Sci Rep. 2021;11:2650. https://pmc.ncbi.nlm.nih.gov/articles/PMC7846568/

⁴ Fabritius HO, et al. Remineralization of molar incisor hypomineralization (MIH) with a hydroxyapatite toothpaste: an in-situ study. BDJ Open. 2022;8:32. https://pmc.ncbi.nlm.nih.gov/articles/PMC9741585/

⁵ Kensche A, et al. Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial. Front Public Health. 2023;11:1199728. https://pmc.ncbi.nlm.nih.gov/articles/PMC10393266/

⁶ Fabritius HO, et al. Hydroxyapatite in Oral Care Products—A Review. Materials (Basel). 2021;14(17):4865. https://pmc.ncbi.nlm.nih.gov/articles/PMC8432723/

⁷ Additional supporting reviews on HA efficacy in oral biofilm and sensitivity.